The gut microbiome has emerged as a critical regulator of human physiology. Gut intestinal lining plays a major role in modulating the interplay of good commensal gut microbes and pathogenic microbes. The close association of gut commensal bacteria and its metabolites helps in proper maturation and modulation of the immune system. However, deleterious changes to the composition or number of gut bacteria, commonly referred to as gut dysbiosis, have been linked to the development and progression of numerous diet-related diseases.

The intestinal barrier function is crucial to maintaining tissue homeostasis. And any compromise or even slight perturbation in epithelial barriers can lead to serious pathological consequences. The intestinal barrier is constantly being challenged by the gut microbiome and dysbiosis is associated with intestinal inflammation and reduced integrity of the gut barrier (1). This, in turn, increases circulating levels of bacterial structural components and microbial metabolites that may facilitate the development of cardiovascular, autoimmune and infectious systemic diseases.


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