A KEY CONTRIBUTOR TO METABOLIC AND
CHRONIC DISEASES & INFLAMMATION
When the core gut microbiome is imbalanced, the normal metabolic profile of the gut flora significantly alters, which can lead to several disease conditions such as autoimmune, digestive and metabolic diseases
Dysbiosis of the gut microbiome is caused by the imbalance between the commensal and pathogenic microbiomes.This occurs when a disturbance in the composition and function of beneficial bacteria makes them incapable of controlling the harmful bacteria successfully.
Several factors can change the gut microbiome on a daily basis; dietary patterns, probiotics, prebiotics, synbiotics, antibiotics, and non-dietary factors, such as, genetics, stress, age, exercise, and climatic conditions, can dramatically impact the human gut microbiota equilibrium and diversity.
Today, gut dysbiosis has been linked with important human diseases, not only infections, but also diseases such as diabetes, liver diseases, inflammatory bowel diseases, irritable bowel syndrome, obesity, diabetes, metabolic syndrome, cardiovascular diseases, allergy, asthma, neurological diseases, several cancers, celiac diseases, obesity, and other chronic conditions.
Microbial dysbiosis is also correlated with gut barrier compromise and bacterial translocation, leading to increased inflammation and endotoxemia
Endotoxins, produced by pathogenic bacteria, stimulated low-grade inflammation was understood as the prime mechanism by which gut microbiota induces obesity. Supplementation of prebiotics and probiotics addressed therapeutic effect on the altered gut microbiota that provides us an opportunity to prevent or treat obesity.