Being trained as a microbiology and immunology researcher, I knew one thing very well: bacterial physiology and its interaction with human. Knowing how to grow bacteria optimally, how to selectively evolve them, how to preserve and store them, and how to kill them are all critical for several areas in health and consumer care. Using this knowledge and expertise, I worked on a whole range of projects such as a probiotic bacterial cocktail for animal feeds and the profiling of nosocomial drug-resistant bacteria in hospitals, as well as designing novel biocides, studying the genomics of bacterial flora of mosquitos, and engineering the complex microbial ecosystem of oil-gas wells.
The results published by the NIH led Human Microbiome Project (HMP) in 2012 were staggering to me. The HMP showed that we are superorganisms composed of both human and microbial components. Even though I appreciated the vastness of several microbial ecosystems, just the thought that we are carrying the most complex microbial ecosystem in the whole planet was an epiphany for me. Yes, commensal microbial flora is ‘the most’ complex microbial ecosystems ever studied.
An average human carries almost two to three pounds of microbiota comprising of approximately 40 trillion cells of over 1000 different types of microbes! Not just that, these microbes will co-evolve with an individual, starting at their birth, into a core microbiota that specifically works in tandem with your physiology and genetics. There is quite a bit of two-way communication between our commensal microbes and our cells to enhance every bit of our being, whether it is through digestion, enzyme production, cognition, the circadian rhythm, bowel movement, or hormone production. Personally, I feel that the beauty lies in the fact that the three million genes of the microbiome fine-tune the 30,000 genes in the human genome, promoting health and longevity.
When I realized these microbes are not just bystanders but a vital organ that modulates human physiology, it felt natural to passionately and productively use my scientific expertise to contribute something to this sector. Two to three years of work resulted in a start-up venture, Biom Pharmaceutical Corporation. Biom Pharma specifically develops products and services in the microbiome sector.
One of the first actions that was taken was to re-evaluate the current probiotic products in the market place. Ironically, about 80-90% of the probiotic products in the marketplace do not even have labeled potency. While some may have some incremental digestive benefits, none of them are designed to modulate the human microbiome. I have invested significant time and resources to develop a new generation of effective microbiome modulating probiotics, the result of which was Biom Probiotics. I have carefully blended a mix of selective prebiotics and organic plant extracts into a complex called the Microbiome Diversifying Complex (MDP). This prebiotic complex can significantly diversify your gut microbiome, a major index of microbiome balance and homeostasis. The more diverse your gut microbiome is the better it will be at promoting health and disease-prevention.
Together with MDC, I have formulated fifteen clinically-tested probiotic strains with immunobiotics LP-20 (a clinically-tested and very popular Japanese supplement). These formulations synergistically balance and diversify your microbiome to promote health and longevity. This is a key supplement that should be added to a preventative care regime as a means of improving long-term quality of life. This is just the beginning; I am looking to extend the technologies that I developed to help people with various diseases, such as autism, Alzheimer’s, HIV, and many others.
It is an exciting time in personalized and clinical medicine. Microbiome complementing functional supplements such as Biom Probiotics are going to be a key component in the future of personalized medicine and longevity research. I am thrilled and excited to be part of this emerging theme of medical research. I cannot wait to update you more of what we are doing at Biom Pharmaceutical.
In Good Health,
Bobban Subhadra, M.S., Ph.D